Mother Harlot follows a set pattern: She will always cast Babylon Goblet first, then follow up with Mind Break.
With 4 Press Turns, the boss phase goes as such: Fenrir --> Mother Harlot --> Tlaltecuhtli --> Fenrir. If you keep the adds alive, MH will never use Mind Break.
This also means she will never get the bonus damage from Death Lust+ if you can cleanse the Charm away each turn.
The boss has no offensive buffs/debuffs: once you cast Tarunda and Rakukaja, she has no way of removing them. Abuse this to make her damage more tankable.
The boss has no barrier break, Ward brands will give you 3 turns of status protection, which is enough for you to recast it on your whole team before it expires.
Alternately, you could just bring a cleric like Kinmamon to cleanse Charm.
This is a fairly straightforward battle of attrition. Bring a healer, a cleric, a buff support and a DPS demon, and slowly chip her down.
Lydia is a great skill for this fight, as it has no usage limits.
For DPS units, consider a strong ST nuke that costs 6 MP or less. MH will drain 2 MP per turn, if you plan to run >6 MP moves, run divine brands instead.
As MH and Fenrir will only cast AOE skills, Hecatoncheires is a great support as his passive will reduce their damage, and you can use him as a buff/debuff bot.
Combat stats use the screenshot’s level, STR, MAG and VIT with the base stat formulas. Enemy skill bonuses are not included. HP is the recorded maximum.
Sources
Orthrus · original encounter screenKelpie · original encounter screen
Wave 2:
Difficulty AEditorial estimate
FEDCBAS
A demanding challenge with revival pressure, barrier removal; plan counters and sustained recovery.
Recommended demonsKit-based options · reviewed 14 Oct 2026
Cleanse Charm each turn and keep buffs favorable. The documented turn order can stop Mind Break while the adds live, so do not indiscriminately clear them with uncontrolled AoEs.
DaisoujouSummon / multifusionAilment and debuff control
His own ailment immunity lets him lead with Cleansing Shout against Babylon Goblet Charm. This restores the party’s ability to act, removes debuffs and recovers MP without an HP-healing effect.
Golden Apple adds natural MP recovery and Fortify-based protection for the Charm and MP attrition. A fallen ally can be revived once per turn if revival is permitted.
Setup: Panel 1 for personal ailment immunity/Null Mortal.
Watch out: Revival is not a substitute for removing enemies that seal it.
Combat stats use the screenshot’s level, STR, MAG and VIT with the base stat formulas. Enemy skill bonuses are not included. HP is the recorded maximum.
Sources
Tlaltecuhtli · original encounter screenMother Harlot · original encounter screenFenrir · original encounter screen
Seiran is the preferred Dx2 as she will provide random healing and increase healing effectiveness.
Kinmamon is used as a cleric to clear away charm. Keep weakness open to increase damage reduction from Orcus.
Mahakala has strong piercing fire DPS which also drops the boss's defense, cancelling out the Defense boost from Fenrir. He also grants free AOE damage every 3 turns, plus concentrate to let him nuke even harder.
Amaterasu is used for buffing and healing. Her weakness is also kept open for the same reasons as Kinmamon.
Orcus provides passive damage reduction and buff/debuff control. Samarecarm as a safety net just in case.
I killed Mother Harlot first, then Fenrir and lastly Tlaltecuhtli.
Same Strategy as Reika, nuke MH down first. Indra provides 5e after that, which will make the fight pretty much auto-win if you manage to kill her once, as Fenrir will revive her, which creates an easy kill for you.
A bit more luck is needed as with Maha, as you dont get the AoE and Conc Effect.
Just ST on MH, hope HT Hits stick. Pray that you arent dying on her turn and that charm will wear off. Needed 4 tries. Please dont torture yourself, I just wanted to beat it with a phys T1-ish team.